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An esterified form of DHA; increases plasma and erythrocyte membrane DHA levels in rats without altering arachidonic acid levels when administered in the diet to at a dose equivalent to 8 mg/kg of DHA; reduces the number of reference memory errors in an eight-arm radial maze in 100-week old rats at 300 mg/kg
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An esterified form of trans-vaccenic acid; has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS
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γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
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A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
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A phenol with diverse biological activities; scavenges DPPH and hydroxyl radicals in cell-free assays (IC50s = 9.4 and 191 µM, respectively); reverses abscisic acid-induced inhibition of hypocotyl growth in A. caudatus seedlings from 1-100 µM; inhibits morpholine- and sodium nitrite-induced adenocarcinoma formation in mice at 21.8 g/kg; inhibits passive cutaneous anaphylaxis in mice at 50 mg/kg
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A naturally occurring fatty acid methyl ester; has been found in the cuticular wax of P. abies needles; has been found in sediment samples from the Harney River in Florida and Lake Kivu in the EAst African rift valley
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γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
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A taurine-conjugated form of CDCA; serum levels increase approximately 5-fold in within two hours and begin to decrease within four hours during an oral lipid tolerance test in humans; serum levels are increased in patients with liver cirrhosis and may serve as a marker of disease progression
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